Prof. Dr. med. dent. Matthias Zehnder, PhD
Head, Division of Endodontology
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Clinical Specialisations
Endodontology
Research Interests
My main research interest is to identify new ways to disinfect and fill dental hard tissues. Further interests include molecular markers to improve pulpal and periapical diagnostics and the electrochemical treatment of peri-implantitis.
Selected publications
De-Deus G, Pinho MA, Reis C, Fidel S, Souza E, Zehnder M. NaOCl with reduced surface tension does not improve in situ pulp tissue dissolution. J Endod 39: 1039-43 (2013)
Rechenberg D, Thurnheer T, Zehnder M. Potential systematic error in laboratory experiments on microbial leakage through filled root canals: experimental study. Int Endod J 44: 827-35 (2011)
Mohn D, Zehnder M, Stark WJ, Imfeld T. Electrochemical disinfection of dental implants – a proof of concept. PLoS one 6:e 16157 (2011)
Zehnder M, Wegehaupt F, Attin T. A first study on the usefulness of MMP-9 from dentinal fluid to indicate pulp inflammation. J Endod 37:17-20 (2011)
Mohn D, Bruhin C, Luechinger NA, Stark WJ, Imfeld T, Zehnder M. Composites made of flame-sprayed bioactive glass 45S5 and polymers: bioactivity and immediate sealing properties. Int Endod J 43:1037–1046 (2010)
Waltimo T, Brunner TJ, Vollenweider M, Stark WJ, Zehnder M. Antimicrobial effect of nanometric bioactive glass 45S5. J Dent Res 86, 754-757 (2007)
Links
Publications in ZORA (Zurich Open Repository and Archive)
ZORA Publication List
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Publications
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Treatment options for permanent teeth with deep caries. Swiss Dental Journal, 126(11):1007-1027.
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Advances in endodontics: Potential applications in clinical practice. Journal of Conservative Dentistry, 19(3):199-206.
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Incorporation of particulate bioactive glasses into a dental root canal sealer. Biomedical glasses, 2(1):29-37.
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Comparison of two contemporary rotary systems in a pre-clinical student course setting. International Endodontic Journal, 49(6):591-598.
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On the dynamics of root canal infections - what we understand and what we don't. Virulence, 6(3):216-222.
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Endodontics and Periodontics (chapter 41). In: Lindhe, J; Lang, Niklaus P. Clinical Periodontology and Implant Dentistry. Chichester, West Sussex: Wiley-Blackwell, 830-860.
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SADMFR Guidelines for the Use of Cone-Beam Computed Tomography/Digital Volume Tomography. Swiss Dental Journal, 125(9):945-953.
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Available chlorine consumption from NaOCl solutions passively placed in instrumented human root canals. International Endodontic Journal, 48(5):435-440.
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Comparison of vehicles to collect dentinal fluid for molecular analysis. Journal of Dentistry, 42(8):1027-1032.
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Effect of low direct current on anaerobic multispecies biofilm adhering to a titanium implant surface. Clinical Implant Dentistry and Related Research, 16(4):552-556.
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Shrinkage of backfill gutta-percha upon cooling. Journal of Endodontics, 40(5):721-724.
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Fibrin gel improves tissue ingrowth and cell differentiation in human immature premolars implanted in rats. Journal of Endodontics, 40(2):246-250.
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Effect of direct current on surface structure and cytocompatibility of titanium dental implants. International Journal of Oral & Maxillofacial Implants, 29(3):735-742.
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Periapical fluid RANKL and IL-8 are differentially regulated in pulpitis and apical periodontitis. Cytokine, 69(1):116-119.
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Molecular diagnostics in endodontics. Endodontic Topics, 30(1):51-65.
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Functionalizing a dentin bonding resin to become bioactive. Dental Materials, 30(8):868-875.
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Historical perspectives on the roots of the apical negative pressure irrigation technique in endodontics. Journal of the History of Dentistry, 62(1):32-40.
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Identification of Synergistetes in endodontic infections. Microbial Pathogenesis, 73:1-6.
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A new method to assess available chlorine in small volumes of liquid. Journal of Endodontics, 40(4):534-537.
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Sodium hypochlorite with reduced surface tension does not improve in situ pulp tissue dissolution. Journal of Endodontics, 39(8):1039-1043.
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Occurrence of cervical invasive root resorption in first and second molar teeth of orthodontic patients eight years after bracket removal. Journal of Endodontics, 39(1):27-30.
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The receptor activator of NF-κB ligand-osteoprotegerin system in pulpal and periapical disease. International Endodontic Journal, 46(2):99-111.
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Research that matters – irrigants and disinfectants. International Endodontic Journal, 45(11):961-962.
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Reduction of hard-tissue debris accumulation during rotary root canal instrumentation by etidronic acid in a sodium hypochlorite irrigant. Journal of Endodontics, 38(5):692-695.
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Continuous chelation irrigation improves the adhesion of epoxy resin-based root canal sealer to root dentine. International Endodontic Journal, 45(12):1097-1102.
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Use of NIR light and upconversion phosphors in light-curable polymers. Dental materials : official publication of the Academy of Dental Materials, 28(3):304-311.
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Physicochemical and pulp tissue dissolution properties of some household bleach brands compared with a dental sodium hypochlorite solution. Journal of endodontics, 38(3):372-375.
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Smear layer dissolution by peracetic acid of low concentration. International Endodontic Journal, 44(6):485-490.
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Elektrochemische Desinfektion dentaler Implantate - eine Machbarkeitsstudie. Implantologie, 19(2):151-159.
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Potential systematic error in laboratory experiments on microbial leakage through filled root canals: an experimental study. International Endodontic Journal, 44(9):827-835.
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Potential systematic error in laboratory experiments on microbial leakage through filled root canals: review of published articles. International Endodontic Journal, 44(3):183-194.
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Microtomography-based comparison of reciprocating single-file F2 ProTaper technique versus rotary full sequence. Journal of Endodontics, 37(10):1394-1397.
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Accumulated hard tissue debris levels in mesial roots of mandibular molars after sequential irrigation steps. International Endodontic Journal, 44(2):148-153.
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Incorporation of reactive silver-tricalcium phosphate nanoparticles into polyamide 6 allows preparation of self-disinfecting fibers. Polymer Engineering and Science, 51(1):71-77.
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Stabilizing sodium hypochlorite at high pH: effects on soft tissue and dentin. Journal of Endodontics, 37(5):693-696.
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Electrochemical disinfection of dental implants--a proof of concept. PLoS ONE, 6(1):e16157.
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The impact of root dentine conditioning on sealing ability and push-out bond strength of an epoxy resin root canal sealer. International Endodontic Journal, 44(6):491-8.
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A first study on the usefulness of matrix metalloproteinase 9 from dentinal fluid to indicate pulp inflammation. Journal of Endodontics, 37(1):17-20.
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Composites made of flame-sprayed bioactive glass 45S5 and polymers: bioactivity and immediate sealing properties. International Endodontic Journal, 43(11):1037-1046.
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Radio-opaque nanosized bioactive glass for potential root canal application: evaluation of radiopacity, bioactivity and alkaline capacity. International Endodontic Journal, 43(3):210-217.
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Acoustic hypochlorite activation in simulated curved canals. Journal of Endodontics, 35(10):1408-1411.
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Hard-tissue debris accumulation analysis by high-resolution computed tomography scans. Journal of Endodontics, 35(7):1044-1047.
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The mysterious appearance of enterococci in filled root canals. International Endodontic Journal, 42(4):277-287.
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Topical antimicrobials in endodontic therapy. In: Fouad, A F. Endodontic microbiology. Ames, Iowa: Wiley-Blackwell, 242-260.
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Fine-tuning of bioactive glass for root canal disinfection. Journal of Dental Research, 88(3):235-238.
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Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the smear layer. International Endodontic Journal, 42(4):335-343.
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Comparative assessment of time-related bioactive glass and calcium hydroxide effects on mechanical properties of human root dentin. Dental Traumatology, 25(1):126-129.
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Necrotic pulp tissue dissolution by passive ultrasonic irrigation in simulated accessory canals: impact of canal location and angulation. International Endodontic Journal, 42(1):59-65.
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Do bioactive glasses convey a disinfecting mechanism beyond a mere increase in pH?. International Endodontic Journal, 41(8):670-678.
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Impact of growth conditions on susceptibility of five microbial species to alkaline stress. Journal of Endodontics, 34(5):579-82.