ExtraordinariusCraniofacial and Oral Biotechnology
In cranio-maxillofacial and oral surgery the substitution of a mandible to restore resections of tumors for example, still poses a great challenge. To overcome this problem our oral Biotechnology and Bioengineering laboratory works on the development of new osteoconductive bone substitute materials and their combination with osteoinductive bone morphogenetic proteins. The materials we use and develop range from degradable polylactide based materials, to natural and synthetic hydrogels, like fibrin and polyethylenglycol-(PEG)-based hydrogels, to titanium based scaffolds produced in a patient specific shape by selective laser melting and rapid prototyping. The delivery of osteoinductive bone morphogenetic proteins, including enhancers of bone morphogenetic proteins and degradable, bioactive guided bone regeneration membranes are other fields of expertise of our laboratory. Recently, we started working on the regeneration of pulp-tissue using natural and synthetic hydrogels and diverse factors, produced in our laboratory.
N., Zehnder M., Weber FE (2014)
Fibrin Gel Improves Tissue Ingrowth and Cell Differentiation in Human Immature
Premolars Implanted in Rats
Journal of Endodontics in press
de Wild, M.,
Schumacher, R. Mayer, K. Schkommodau, E., Thoma, D., Bredell, M., Kruse -Gujer, A., Grätz, KW, Weber, FE. (2013) Bone regeneration by
the osteoconductivity of porous titanium implants manufactured by selective
laser melting: A histological and µCT study in the rabbit
Tissue Engineering Part A: in press
Jung UW, Jung RE, Choi KH, Cho KS, Hämmerle CH, Weber F.E. (2012)
Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone
mineral as delivery systems for glycosylated and non-glycosylated bone
Acta Biomater 8:116–123
Sala A, Hänseler
P, Ranga A, Lutolf MP, Vörös J, Ehrbar M, Weber FE. (2011). Engineering 3D cell instructive microenvironments by
rational assembly of artificial extracellular matrices and cell patterning.
Integr. Biol. 3 (11):1102 – 1111
Correro R.M., Lange K., Karfeld-Sulzer L.S., Graetz K.W., Weber F.E.
(2011) Inhibition of osteoclast differentiation and bone resorption by N-methyl
J Biol Chem. 286: 24458–24466
B., Ghayor Ch, Ehrbar M., Jung R.E., Zwahlen R.A., Hortschansky P., Schmoekel H.G., Weber F.E. (2009)
The chemical NMP as a potent BMP enhancer for bone tissue regeneration
Tissue Engineering (Part A) 15 (10): 2955-2963
Lutolf, M.P., Weber,F.E., Schmoekel,
H.G., Schense, J.C., Kohler, T., Müller, R. and J.A. Hubbell (2003) Repair of
bone defects using synthetic mimetics of collagenous extracellular matrices.
Nature Biotechnol. 21: 513-518