Prof. Dr. rer nat. Franz E. Weber

ExtraordinariusCraniofacial and Oral Biotechnology

Contact: E-Mail: franz.weber@zzm.uzh.ch
Qualifications: PhD, PD, Oral Biology, Biology and Biochemistry
Affiliation: Cranio-Maxillofacial and Oral Surgery

Research Interests

In cranio-maxillofacial and oral surgery the substitution of a mandible to restore resections of tumors for example, still poses a great challenge. To overcome this problem our oral Biotechnology and Bioengineering laboratory works on the development of new osteoconductive bone substitute materials and their combination with osteoinductive bone morphogenetic proteins. The materials we use and develop range from degradable polylactide based materials, to natural and synthetic hydrogels, like fibrin and polyethylenglycol-(PEG)-based hydrogels, to titanium based scaffolds produced in a patient specific shape by selective laser melting and rapid prototyping. The delivery of osteoinductive bone morphogenetic proteins, including enhancers of bone morphogenetic proteins and degradable, bioactive guided bone regeneration membranes are other fields of expertise of our laboratory. Recently, we started working on the regeneration of pulp-tissue using natural and synthetic hydrogels and diverse factors, produced in our laboratory.

Selected publications

Roungsawasdi, N., Zehnder M., Weber FE (2014) Fibrin Gel Improves Tissue Ingrowth and Cell Differentiation in Human Immature Premolars Implanted in Rats
Journal of Endodontics in press

de Wild, M., Schumacher, R. Mayer, K. Schkommodau, E., Thoma, D.,  Bredell, M., Kruse -Gujer, A., Grätz, KW, Weber, FE. (2013) Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit
Tissue Engineering Part A: in press

Hänseler P, Jung UW, Jung RE, Choi KH, Cho KS, Hämmerle CH, Weber F.E. (2012) Analysis of hydrolyzable polyethylene glycol hydrogels and deproteinized bone mineral as delivery systems for glycosylated and non-glycosylated bone morphogenetic protein-2.
Acta Biomater 8:116–123

Sala A, Hänseler P, Ranga A, Lutolf MP, Vörös J, Ehrbar M, Weber FE. (2011). Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning.
Integr. Biol. 3 (11):1102 – 1111

Ghayor C., Correro R.M., Lange K., Karfeld-Sulzer L.S., Graetz K.W., Weber F.E. (2011) Inhibition of osteoclast differentiation and bone resorption by N-methyl pyrrolidone.
J Biol Chem. 286: 24458–24466

San Miguel B., Ghayor Ch, Ehrbar M., Jung R.E., Zwahlen R.A., Hortschansky  P., Schmoekel H.G., Weber F.E. (2009) The chemical NMP as a potent BMP enhancer for bone tissue regeneration
Tissue Engineering (Part A) 15 (10): 2955-2963

Lutolf, M.P., Weber,F.E., Schmoekel, H.G., Schense, J.C., Kohler, T., Müller, R. and J.A. Hubbell (2003) Repair of bone defects using synthetic mimetics of collagenous extracellular matrices.
Nature Biotechnol. 21: 513-518

Links

Publications in ZORA (Zurich Open Repository and Archive)

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